A series of grand artworks fills the sanctuary, among them are the Gothic altarpiece of the Chapel of Santa Barbara and the 16th century tombs of the Chapel of San Francisco. The Chapel of the Incarnation contains a neoclassic altarpiece (1785) designed by the sculptor Juan de Villanueva and carved by Antonio Ramos and Aldehuela, a group of figures representing the Annunciation and sculptures of the patron saints of Malaga, Saint Ciriaco and Saint Paula, carved by Juan Salazar Palomino also in the 18th century, and The Beheading of Saint Paul, painted by Enrique Simonet in 1887 during his stay in Rome.